Beyond conventional immune-checkpoint inhibition—novel immunotherapies for renal cell carcinoma

DA Braun, Z Bakouny, L Hirsch, R Flippot… - Nature reviews Clinical …, 2021 - nature.com
The management of advanced-stage renal cell carcinoma (RCC) has been transformed by
the development of immune-checkpoint inhibitors (ICIs). Nonetheless, most patients do not …

[HTML][HTML] Beyond conventional immune checkpoint inhibition: renal cell carcinoma at the forefront of solid tumor immunology

DA Braun, Z Bakouny, L Hirsch, R Flippot… - Nature reviews …, 2021 - ncbi.nlm.nih.gov
The management of advanced renal cell carcinoma (RCC) has been transformed by the
development of immune checkpoint inhibitors (ICIs), but still most RCC patients do not …

Outcomes of patients with metastatic renal cell carcinoma with sarcomatoid dedifferentiation to immune checkpoint inhibitors

J Chahoud, P Msaouel, JA Ross, BZ McCormick… - … Oncology: Seminars and …, 2021 - Elsevier
Introduction Metastatic renal cell carcinoma with sarcomatoid dedifferentiation (sRCC) is
associated with poor survival outcomes. We aimed to analyze the efficacy and safety of …

9p21 loss defines the evolutionary patterns of aggressive renal cell carcinomas

F Carbone, JK Huang, L Perelli, ED Poggetto… - bioRxiv, 2020 - biorxiv.org
Dedifferentiation and acquisition of chromosomal instability in renal cell carcinoma portends
dismal prognosis and aggressive clinical behavior. However, the absence of reliable …