Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Intractable neuropathic pain is a frequent consequence of nerve injury or disease. When
peripheral nerves are injured, damaged axons undergo Wallerian degeneration. Schwann …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Neuropathic pain associated with cancers was caused by tumor itself or tumor therapy,
which was aggravated by sensitizing nociceptor sensory neurons. The tumor …

Rationale Drug combinations are commonly used in pain management, which can produce
potent analgesic effects with reduced dosage and adverse effects. Objective This study was …

Background and objective Neuropathic pain (NeP) induced dysbiosis of intestinal microbiota
in chronic constriction injury (CCI) rats. Emodin has analgesic effect but the detailed …

H-1 antihistamines are commonly used in dermatological practice for itch and urticaria
control. The widespread expression of H-1 receptor on different cells in the skin and various …

The development of novel analgesics for chronic pain in the last 2 decades has proven
virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects …

Clinical and animal studies have shown that acupuncture may benefit controlling
neuropathic pain. However, the underlying molecular mechanisms are poorly understood. In …