Ovine pulmonary adenocarcinoma (OPA), also known as jaagsiekte, is a transmissible lung
tumour of sheep caused by jaagsiekte sheep retrovirus (JSRV). JSRV induces neoplastic …

The transmission of viruses from one host to another typically occurs through horizontal or
vertical pathways. The horizontal pathways include transmission amongst individuals …

Endogenous betaretroviruses (enJSRVs) of sheep are expressed abundantly in the female
reproductive tract and play a crucial role in conceptus development and placental …

Jaagsiekte Sheep Retrovirus (JSRV) is a betaretrovirus infecting sheep. This virus is
responsible for a pulmonary adenocarcinoma, by transformation of epithelial cells from the …

Lung cancer represents a major worldwide health concern; although advances in patient
management have improved outcomes for some patients, overall 5-year survival rates are …

Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary
adenocarcinoma (OPA). The expression of the JSRV envelope (Env) alone is sufficient to …

Over the past decade, immune therapy has become a standard treatment for a variety of
cancers. Monoclonal antibodies, immune adjuvants and vaccines against oncogenic viruses …

Background Jaagsiekte sheep retrovirus (JSRV) causes a lethal lung cancer in sheep and
goats. Expression of the JSRV envelope (Env) protein in mouse lung, by using a replication …

Sheep betaretroviruses represent a fascinating model to study the complex evolutionary
interplay between host and pathogen in natural settings. In infected sheep, the exogenous …

Simple Summary Neoplasia is a common cause of weight loss and emaciation. Despite its
relative infrequency in sheep, there are three neoplastic diseases with special relevance …