Abstract N 6-methyladenosine (m6A) maintains maternal RNA stability in oocytes. One
regulator of m6A, ALKBH5, reverses m6A deposition and is essential in RNA metabolism …

Meiotic maturation and cumulus expansion are essential for the generation of a
developmentally competent gamete, and both processes can be recapitulated in vitro. We …

Introduction Morphokinetic analysis using a closed time-lapse monitoring system
(EmbryoScope+™) provides quantitative metrics of meiotic progression and cumulus …

Context A genetic etiology likely accounts for the majority of unexplained primary ovarian
insufficiency (POI). Objective We hypothesized that heterozygous rare variants and variants …

STUDY QUESTION Are there any differences between in vivo (IVV) and in vitro (IVT)
matured metaphase II (MII) oocytes at the molecular level? SUMMARY ANSWER Between …

Meiosis, a highly conserved process in organisms from fungi to mammals, is subjected to
protein phosphorylation regulation. Due to the low abundance of phosphorylation, there is a …

In somatic cells spindle microtubules are nucleated from centrosomes that act as major
microtubule organizing centers (MTOCs), whereas oocytes form meiotic spindles by …

Cyclin-dependent kinase 7 (CDK7) is a master regulatory kinase that drives cell cycle
progression and stimulates expression of oncogenes in a myriad of cancers. Inhibitors of …

Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling
molecules in RNA polymerase II (Pol II) transcriptional control. Our prior work has shown that …

Genomic instability is a characteristic of a majority of human malignancies. Chromosomal
instability is a common form of genomic instability that can be caused by defects in mitotic …