Extracellular matrix in kidney fibrosis: more than just a scaffold

RD Bülow, P Boor - Journal of Histochemistry & …, 2019 - journals.sagepub.com
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

[HTML][HTML] Origin of myofibroblasts and cellular events triggering fibrosis

M Mack, M Yanagita - Kidney international, 2015 - Elsevier
Renal fibrosis is a major hallmark of chronic kidney disease that is considered to be a
common end point of various types of renal disease. To date, the biological meaning of …

Effect of biochemical and biomechanical factors on vascularization of kidney organoid-on-a-chip

HN Lee, YY Choi, JW Kim, YS Lee, JW Choi, T Kang… - Nano …, 2021 - Springer
Kidney organoids derived from the human pluripotent stem cells (hPSCs) recapitulating
human kidney are the attractive tool for kidney regeneration, disease modeling, and drug …

Animal models of sepsis and sepsis-induced kidney injury

K Doi, A Leelahavanichkul, PST Yuen… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Sepsis is characterized by a severe inflammatory response to infection, and its
complications, including acute kidney injury, can be fatal. Animal models that correctly mimic …

Tacrolimus: 20 years of use in adult kidney transplantation. What we should know about its nephrotoxicity

Y Bentata - Artificial organs, 2020 - Wiley Online Library
Abstract Tacrolimus (or FK506), a calcineurin inhibitor (CNI) introduced in field of
transplantation in the 1990s, is the cornerstone of most immunosuppressive regimens in …

Calcineurin inhibitor nephrotoxicity through the lens of longitudinal histology: comparison of cyclosporine and tacrolimus eras

BJ Nankivell, CH P'Ng, PJ O'Connell… - Transplantation, 2016 - journals.lww.com
Background The contribution of calcineurin inhibitors (CNI) nephrotoxicity to progressive
kidney transplant injury remains debated, with little long-term data from the modern …

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

KM Wasan, DR Brocks, SD Lee… - Nature reviews Drug …, 2008 - nature.com
In contrast to many traditional pharmaceutical agents that exhibit a high degree of aqueous
solubility, new drug candidates are frequently highly lipophilic compounds. The aqueous …

Efficacy and safety of treatment with rituximab for difficult steroid-resistant and-dependent nephrotic syndrome: multicentric report

A Gulati, A Sinha, SC Jordan, P Hari… - Clinical Journal of the …, 2010 - journals.lww.com
Background and objectives: The treatment of idiopathic nephrotic syndrome is often
complicated by a refractory and relapsing course, with risk of drug toxicity and progressive …

New insights into postrenal transplant hemolytic uremic syndrome

J Zuber, M Le Quintrec, R Sberro-Soussan… - Nature Reviews …, 2011 - nature.com
After renal transplantation, hemolytic uremic syndrome (HUS) may occur either as a
recurrent or de novo form. Over the past decade, much effort has been devoted to …

Spectrum of complement-mediated thrombotic microangiopathies: pathogenetic insights identifying novel treatment approaches

M Riedl, F Fakhouri, M Le Quintrec… - … in thrombosis and …, 2014 - thieme-connect.com
Thrombotic microangiopathy (TMA) is a rare but severe disorder characterized by
endothelial cell activation and thrombus formation. It manifests with the triad of hemolytic …