The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Cell-free permeation systems are gaining interest in drug discovery and development as
tools to obtain a reliable prediction of passive intestinal absorption without the …

Permeability coefficients across monolayers of the human colon carcinoma cell line Caco-2,
cultured on permeable supports, are commonly used to predict the absorption of orally …

The purpose of this study was to evaluate the use of human intestinal tissue in Ussing
chamber to predict oral and colonic drug absorption and intestinal metabolism. Data on …

The human colon adenocarcinoma Caco-2 and Madin–Darby canine kidney epithelial cell
lines provide in vitro tools to assess a drug's permeability and transporter interactions during …

Models predictive of intestinal drug absorption are important in drug development to identify
compounds with promising biopharmaceutical properties. Since permeability is a factor …

The transport of monocarboxylates, such as lactate and pyruvate, is mediated by the
SLC16A family of proton-linked membrane transport proteins known as monocarboxylate …

The Caco‐2 cell system, a well characterized intestinal in vitro model, makes it possible to
evaluate the ability of chemicals to cross the intestinal barrier, as well as to study their …

Objectives Flavonoids are phenolic compounds found in most edible fruits and vegetables.
Previous studies have demonstrated their biological and beneficial effects on human health …

Non-steroidal anti-inflammatory drugs such as diclofenac exhibit potent anticancer effects.
Up to now these effects were mainly attributed to its classical role as COX-inhibitor. Here we …