The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Epilepsy in adults

RD Thijs, R Surges, TJ O'Brien, JW Sander - The lancet, 2019 - thelancet.com
Epilepsy is one of the most common serious brain conditions, affecting over 70 million
people worldwide. Its incidence has a bimodal distribution with the highest risk in infants and …

Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

A Vezzani, S Balosso, T Ravizza - Nature Reviews Neurology, 2019 - nature.com
Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Revisiting the role of neurotransmitters in epilepsy: An updated review

E Akyuz, AK Polat, E Eroglu, I Kullu, E Angelopoulou… - Life sciences, 2021 - Elsevier
Epilepsy is a neurologicaldisorder characterized by persistent predisposition to recurrent
seizurescaused by abnormal neuronal activity in the brain. Epileptic seizures maydevelop …

Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

The therapeutic role of ketogenic diet in neurological disorders

D Pietrzak, K Kasperek, P Rękawek… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

Classification of epileptic EEG recordings using signal transforms and convolutional neural networks

R San-Segundo, M Gil-Martín… - Computers in biology …, 2019 - Elsevier
This paper describes the analysis of a deep neural network for the classification of epileptic
EEG signals. The deep learning architecture is made up of two convolutional layers for …

Incidence and case fatality rate of COVID-19 in patients with active epilepsy

P Cabezudo-García, NL Ciano-Petersen… - Neurology, 2020 - AAN Enterprises
Objective This article estimates the incidence and fatality of coronavirus disease 2019
(COVID-19) and identifies potential risk factors for fatality in patients with active epilepsy …

Therapeutic strategies to ameliorate neuronal damage in epilepsy by regulating oxidative stress, mitochondrial dysfunction, and neuroinflammation

S Madireddy, S Madireddy - Brain sciences, 2023 - mdpi.com
Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …