Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

The deterioration of neurons in Alzheimer's disease (AD) arises from genetic, immunologic,
and cellular factors inside the cortex. The traditional consensus of the amyloid-beta (Aβ) …

KCNQs are voltage-gated K+ channels that control neuronal excitability and are mutated in
epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in …

Background Clinical and animal studies demonstrated that neuroinflammation from
anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive …

Discovered some 40 years ago, the I f current has since been known as the “pacemaker”
current due to its role in the initiation and modulation of the heartbeat and of neuronal …

Glia and accessory cells regulate the microenvironment around neurons and primary
sensory cells. However, the impact of specific glial regulators of ions and solutes on …

Despite significant advances in our understanding of the pathophysiology of multiple
sclerosis (MS), knowledge about contribution of individual ion channels to axonal …

We investigated whether pharmacological increase of “M-type”(KCNQ, Kv7) K+ channel
currents by the M-channel opener, retigabine (RTG), acutely after repetitive traumatic brain …

Stroke seriously threatens human life and health worldwide, but only very few effective
stroke medicines are currently available. Our previous studies have indicated that the …

Neurodegenerative diseases like Alzheimer's and Parkinson's disease (AD and PD) are well-
known, yet their underlying causes remain unclear. Recent studies have suggested that …