In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

Ring-cleaving dioxygenases catalyze the oxygenolytic fission of catecholic compounds, a
critical step in the aerobic degradation of aromatic compounds by bacteria. Two classes of …

The nine-residue lipodepsipeptide syringomycin E, elaborated as a phytotoxin by
Pseudomonas syringae pv. syringae B301D contains a 4-Cl-l-Thr-9 moiety where failure to …

Enzymatic incorporation of chlorine, bromine or iodine atoms occurs during the biosynthesis
of more than 4,000 natural products. Halogenation can have significant consequences for …

Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic
pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol …

It is now appreciated that the relationships of proteins, particularly enzymes, within a protein
superfamily can be understood not only in terms of their sequence similarities and three …

The purple chromobacterial pigment violacein arises by enzymatic oxidation and coupling of
two molecules of l-tryptophan to give a rearranged pyrrolidone-containing scaffold in the …

Natural product chemical diversity is fuelled by the emergence and ongoing evolution of
biosynthetic pathways in secondary metabolism. However, co-evolution of enzymes for …

KshAB (3-Ketosteroid 9α-hydroxylase) is a two-component Rieske oxygenase (RO) in the
cholesterol catabolic pathway of Mycobacterium tuberculosis. Although the enzyme has …

The catalytic mechanism of the non-heme iron extradiol dioxygenases has been studied
using hybrid density functional theory. These enzymes cleave a C− C bond outside the two …