Methods and applications for single-cell and spatial multi-omics

K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …

[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective

LM O'Connor, BA O'Connor, SB Lim, J Zeng… - Journal of …, 2023 - Elsevier
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

S Lee, G Kim, JY Lee, AC Lee, S Kwon - Molecular Cancer, 2024 - Springer
Technologies to decipher cellular biology, such as bulk sequencing technologies and single-
cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent …

Revealing spatial multimodal heterogeneity in tissues with SpaTrio

P Yang, L Jin, J Liao, K Jin, X Shao, C Li, J Qian… - Cell Genomics, 2023 - cell.com
Capturing and depicting the multimodal tissue information of tissues at the spatial scale
remains a significant challenge owing to technical limitations in single-cell multi-omics and …