Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
Mechanisms of NMDA receptor regulation
L Mony, P Paoletti - Current opinion in neurobiology, 2023 - Elsevier
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key role in brain development and …
expressed in the central nervous system that play key role in brain development and …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
NMDA receptors: linking physiological output to biophysical operation
GJ Iacobucci, GK Popescu - Nature Reviews Neuroscience, 2017 - nature.com
NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which
respond to glutamate in a manner that integrates multiple external and internal cues. They …
respond to glutamate in a manner that integrates multiple external and internal cues. They …
Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology
KK Ogden, W Chen, SA Swanger, MJ McDaniel… - PLoS …, 2017 - journals.plos.org
N-methyl-D-aspartate receptors (NMDARs), ligand-gated ionotropic glutamate receptors,
play key roles in normal brain development and various neurological disorders. Here we …
play key roles in normal brain development and various neurological disorders. Here we …
[HTML][HTML] Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy
Abstract NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in
various neurological disorders, including epilepsy. Here we show the functional analysis of …
various neurological disorders, including epilepsy. Here we show the functional analysis of …
Structural insights into NMDA receptor pharmacology
C Zhou, N Tajima - Biochemical Society Transactions, 2023 - portlandpress.com
N-methyl-d-aspartate receptors (NMDARs) comprise a subfamily of ionotropic glutamate
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
receptors that form heterotetrameric ligand-gated ion channels and play fundamental roles …
Glycine-dependent activation of NMDA receptors
KA Cummings, GK Popescu - Journal of General Physiology, 2015 - rupress.org
N-methyl-d-aspartate (NMDA) receptors are the only neurotransmitter receptors whose
activation requires two distinct agonists. Heterotetramers of two GluN1 and two GluN2 …
activation requires two distinct agonists. Heterotetramers of two GluN1 and two GluN2 …
From bedside‐to‐bench: What disease‐associated variants are teaching us about the NMDA receptor
JB Amin, GR Moody, LP Wollmuth - The Journal of physiology, 2021 - Wiley Online Library
NMDA receptors (NMDARs) are glutamate‐gated ion channels that contribute to nearly all
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …
brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR …