The transforming growth factor-β (TGF-β) system signals via protein kinase receptors and
SMAD mediators to regulate a large number of biological processes. Alterations of the TGF …

Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …

TGF-β1 is a ubiquitous growth factor that is implicated in the control of proliferation,
migration, differentiation, and survival of many different cell types. It influences such diverse …

Breast cancer (BC) is potentially life‐threatening malignancy that still causes high mortality
among women. Scientific research in this field is focused on deeper understanding of …

Cytokines, signaling proteins produced by a variety of cell types, are essential for the
development and functioning of both innate and adaptive immune response. Cytokine gene …

Single-nucleotide polymorphisms (SNP) associated with polygenetic disorders, such as
breast cancer (BC), can create, destroy, or modify microRNA (miRNA) binding sites; …

Background Polymorphisms in genes other than the cystic fibrosis transmembrane
conductance regulator (CFTR) gene may modify the severity of pulmonary disease in …

Known genetic loci explain only a small proportion of the familial relative risk of colorectal
cancer (CRC). We conducted a genome-wide association study of CRC in East Asians with …

Abstract The Breast Cancer Association Consortium (BCAC) has been established to
conduct combined case-control analyses with augmented statistical power to try to confirm …

Here we report a microfluidics method to enrich physically deformable cells by mechanical
manipulation through artificial microbarriers. Driven by hydrodynamic forces, flexible cells or …