An overview of microRNAs: Biology, functions, therapeutics, and analysis methods

K Saliminejad, HR Khorram Khorshid… - Journal of cellular …, 2019 - Wiley Online Library
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in
posttranscriptional regulation of gene expression. They are powerful regulators of various …

Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

An estimate of the total number of true human miRNAs

J Alles, T Fehlmann, U Fischer, C Backes… - Nucleic acids …, 2019 - academic.oup.com
While the number of human miRNA candidates continuously increases, only a few of them
are completely characterized and experimentally validated. Toward determining the total …

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

M Li, G Santpere, Y Imamura Kawasawa, OV Evgrafov… - Science, 2018 - science.org
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

PUC Dinh, D Paudel, H Brochu, KD Popowski… - Nature …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in
which persistent injury results in scar tissue formation. As fibrosis thickens, the lung tissue …

[HTML][HTML] Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy

E Wyler, K Mösbauer, V Franke, A Diag, LT Gottula… - IScience, 2021 - cell.com
Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

M Piwecka, P Glažar, LR Hernandez-Miranda… - Science, 2017 - science.org
INTRODUCTION Recently, a special class of RNAs has excited researchers and triggered
hundreds of now-published studies. Known as circular RNAs (circRNAs), these RNAs are …

A genomic and epigenomic atlas of prostate cancer in Asian populations

J Li, C Xu, HJ Lee, S Ren, X Zi, Z Zhang, H Wang, Y Yu… - Nature, 2020 - nature.com
Prostate cancer is the second most common cancer in men worldwide. Over the past
decade, large-scale integrative genomics efforts have enhanced our understanding of this …

InsectBase 2.0: a comprehensive gene resource for insects

Y Mei, D Jing, S Tang, X Chen, H Chen… - Nucleic acids …, 2022 - academic.oup.com
Insects are the largest group of animals on the planet and have a huge impact on human life
by providing resources, transmitting diseases, and damaging agricultural crop production …

An integrated expression atlas of miRNAs and their promoters in human and mouse

D De Rie, I Abugessaisa, T Alam, E Arner, P Arner… - Nature …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As
part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) …