Click chemistry strategies for the accelerated synthesis of functional macromolecules

Z Geng, JJ Shin, Y Xi, CJ Hawker - Journal of Polymer Science, 2021 - Wiley Online Library
Click chemistry is one of the most powerful strategies for constructing polymeric soft
materials with precise control over architecture and functionality. In this review, we provide a …

Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

MS Messina, KMM Messina, A Bhattacharya… - Progress in polymer …, 2020 - Elsevier
Biomolecule-polymer conjugates are constructs that take advantage of the functional or
otherwise beneficial traits inherent to biomolecules and combine them with synthetic …

50th Anniversary Perspective: Polymer Functionalization

E Blasco, MB Sims, AS Goldmann, BS Sumerlin… - …, 2017 - ACS Publications
The translation of small molecule chemistries into efficient methodologies for polymer
functionalization spans several decades, enabling critical advances in soft matter materials …

Living radical polymerization by the RAFT process–a third update

G Moad, E Rizzardo, SH Thang - Australian Journal of Chemistry, 2012 - CSIRO Publishing
This paper provides a third update to the review of reversible deactivation radical
polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC (= S) SR) by a …

“Click”-inspired chemistry in macromolecular science: matching recent progress and user expectations

P Espeel, FE Du Prez - Macromolecules, 2015 - ACS Publications
This year, it has been a decade that the concept of “click” chemistry was pioneered in
polymer and material science by the exploration of the synthetic scope of copper-catalyzed …

Dimeric drug polymeric micelles with acid‐active tumor targeting and FRET‐traceable drug release

X Guo, L Wang, K Duval, J Fan, S Zhou… - Advanced …, 2018 - Wiley Online Library
Trans‐activating transcriptional activator (TAT), a cell‐penetrating peptide, is extensively
used for facilitating cellular uptake and nuclear targeting of drug delivery systems. However …

Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies

H Liu, HH Lu, Y Alp, R Wu, S Thayumanavan - Progress in Polymer …, 2024 - Elsevier
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …

Conjugation-induced fluorescent labeling of proteins and polymers using dithiomaleimides

MP Robin, P Wilson, AB Mabire… - Journal of the …, 2013 - ACS Publications
Dithiomaleimides (DTMs) with alkyl substituents are shown to be a novel class of highly
emissive fluorophores. Variable solubility and further functionalization can easily be tailored …

Homopolymer bifunctionalization through sequential thiol–epoxy and esterification reactions: an optimization, quantification, and structural elucidation study

I Gadwal, MC Stuparu, A Khan - Polymer Chemistry, 2015 - pubs.rsc.org
In this study, we probe various aspects of a post-polymerization double-modification strategy
involving sequential thiol–epoxy and esterification reactions for the preparation of dual …

Tuning the Diels–Alder reaction for bioconjugation to maleimide drug-linkers

AH St. Amant, D Lemen, S Florinas, S Mao… - Bioconjugate …, 2018 - ACS Publications
The thiol–maleimide linkage is widely used for antibody–drug conjugate (ADC) production;
however, conjugation of maleimide–drugs could be improved by simplified procedures and …