The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Distinct tumor microenvironment forms in each progression step of cancer and has diverse
capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now …

Myeloperoxidase (MPO) belongs to the family of heme-containing peroxidases, produced
mostly from polymorphonuclear neutrophils. The active enzyme (150 kDa) is the product of …

Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …

Acute ischemic stroke is a serious life‐threatening disease that affects almost 600 million
people each year throughout the world with a mortality of more than 10%, while two‐thirds of …

Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, is considered
one of the most common causes of dementia worldwide, accounting for about 80% of all …

Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

Background: Atherosclerotic cardiovascular diseases are characterized by a dysregulated
inflammatory and thrombotic state, leading to devastating complications with increased …

Atherothrombosis is a frequent cause of cardiovascular mortality. It is mostly triggered by
plaque rupture and exposure of the thrombogenic subendothelial matrix, which initiates …

Myeloperoxidase is a signature enzyme of polymorphonuclear neutrophils in mice and
humans. Being a component of circulating white blood cells, myeloperoxidase plays multiple …