Inflammation must be tightly regulated to both defend against pathogens and restore tissue
homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated …

Macrophages are present in all vertebrate tissues and have emerged as multifarious cells
with complex roles in development, tissue homeostasis, and disease. Macrophages are a …

The endogenous electric field (EF) generated by transepithelial potential difference plays a
decisive role in wound reepithelialization. For patients with large or chronic wounds …

Adult mammalian skin wounds heal by forming fibrotic scars. We report that full-thickness
injuries of reindeer antler skin (velvet) regenerate, whereas back skin forms fibrotic scar …

Stimulating regeneration of complex tissues and organs after injury to effect complete
structural and functional repair, is an attractive therapeutic option that would revolutionize …

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

Scarring and regeneration are two physiologically opposite endpoints to skin injuries, with
mammals, including humans, typically healing wounds with fibrotic scars. We aim to provide …

Studying regeneration in animals where and when it occurs is inherently interesting and a
challenging research topic within developmental biology. Historically, vertebrate …

Regeneration of adult mammalian central nervous system (CNS) axons is abortive, resulting
in inability to recover function after CNS lesion, including spinal cord injury (SCI). Here, we …

Spiny mice (Acomys cahirinus) are terrestrial mammals that evolved unique scar-free
regenerative wound-healing properties. Myofibroblasts (MFs) are the major scar-forming cell …