Nanotools for sepsis diagnosis and treatment

L Papafilippou, A Claxton, P Dark… - Advanced …, 2021 - Wiley Online Library
Sepsis is one of the leading causes of death worldwide with high mortality rates and a
pathological complexity hindering early and accurate diagnosis. Today, laboratory culture …

Nano-omics: nanotechnology-based multidimensional harvesting of the blood-circulating cancerome

L Gardner, K Kostarelos, P Mallick, C Dive… - Nature Reviews …, 2022 - nature.com
Over the past decade, the development of 'simple'blood tests that enable cancer screening,
diagnosis or monitoring and facilitate the design of personalized therapies without the need …

Detection of ovarian cancer via the spectral fingerprinting of quantum-defect-modified carbon nanotubes in serum by machine learning

M Kim, C Chen, P Wang, JJ Mulvey, Y Yang… - Nature Biomedical …, 2022 - nature.com
Serum biomarkers are often insufficiently sensitive or specific to facilitate cancer screening
or diagnostic testing. In ovarian cancer, the few established serum biomarkers are highly …

Multiomics analysis of naturally efficacious lipid nanoparticle coronas reveals high-density lipoprotein is necessary for their function

K Liu, R Nilsson, E Lázaro-Ibáñez, H Duàn… - Nature …, 2023 - nature.com
In terms of lipid nanoparticle (LNP) engineering, the relationship between particle
composition, delivery efficacy, and the composition of the biocoronas that form around LNPs …

First-in-human controlled inhalation of thin graphene oxide nanosheets to study acute cardiorespiratory responses

JPM Andrews, SS Joshi, E Tzolos, MB Syed… - Nature …, 2024 - nature.com
Graphene oxide nanomaterials are being developed for wide-ranging applications but are
associated with potential safety concerns for human health. We conducted a double-blind …

Person-specific biomolecular coronas modulate nanoparticle interactions with immune cells in human blood

Y Ju, HG Kelly, LF Dagley, A Reynaldi, TE Schlub… - ACS …, 2020 - ACS Publications
When nanoparticles interact with human blood, a multitude of plasma components adsorb
onto the surface of the nanoparticles, forming a biomolecular corona. Corona composition is …

Design of Multi‐Shelled Hollow Cr2O3 Spheres for Metabolic Fingerprinting

R Li, Y Zhou, C Liu, C Pei, W Shu… - Angewandte Chemie …, 2021 - Wiley Online Library
Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome,
but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for …

Nanoparticle biomolecular corona-based enrichment of plasma glycoproteins for N-glycan profiling and application in biomarker discovery

DN Trinh, RA Gardner, AN Franciosi, C McCarthy… - ACS …, 2022 - ACS Publications
Biomolecular corona formation has emerged as a recurring and important phenomenon in
nanomedicine that has been investigated for potential applications in disease diagnosis. In …

The lipidomic profile of the nanoparticle-biomolecule corona reflects the diversity of plasma lipids

L Papafilippou, A Nicolaou, AC Kendall… - Nanoscale, 2023 - pubs.rsc.org
The spontaneous self-assembly of biomolecules around the surface of nanoparticles (NPs)
once exposed to plasma and other biofluids, has been termed the 'biomolecule corona' …

Silver nanoparticle decorated graphene-based SERS electrode towards procalcitonin detection

F Selimoğlu, ME Ayhan - Vibrational Spectroscopy, 2023 - Elsevier
Monitoring procalcitonin levels (PCT) is critical for early diagnosis of sepsis, chronic disease,
COVID-19 and other time-dependent pathologic cases. In this work, silver nanoparticles …