Extracellular heat shock protein 90 alpha (eHsp90α)'s role in cancer progression and the development of therapeutic strategies

TS Reynolds, BSJ Blagg - European Journal of Medicinal Chemistry, 2024 - Elsevier
Heat shock protein 90 alpha (Hsp90α) is an abundantly expressed and evolutionarily
conserved molecular chaperone. Hsp90α is the inducible Hsp90 isoform, and its expression …

Pan-and isoform-specific inhibition of Hsp90: Design strategy and recent advances

J Yu, C Zhang, C Song - European Journal of Medicinal Chemistry, 2022 - Elsevier
In the past few decades, the development of heat shock protein 90 (Hsp90) inhibitors for
cancer treatment has not stopped. About twenty compounds have been evaluated in the …

Extracellular heat shock protein-90 (eHsp90): everything you need to know

D Jay, Y Luo, W Li - Biomolecules, 2022 - mdpi.com
“Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not
formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone …

HSP90β promotes osteoclastogenesis by dual-activation of cholesterol synthesis and NF-κB signaling

HM Cheng, M Xing, YP Zhou, W Zhang, Z Liu… - Cell Death & …, 2023 - nature.com
Heat shock protein 90β (Hsp90β, encoded by Hsp90ab1 gene) is the most abundant
proteins in the cells and contributes to variety of biological processes including metabolism …

[HTML][HTML] Utility and specificity of plasma heat shock protein 90 alpha, CEA, and CA199 as the diagnostic test in colorectal cancer liver metastasis

Q Ding, Y Sun, J Zhang, Y Yao, D Huang… - Journal of …, 2022 - ncbi.nlm.nih.gov
Background Plasma heat shock protein 90 alpha (Hsp90α) has been suggested as a novel
biomarker for the diagnosis and prognosis of cancer. Carcinoembryonic antigen (CEA) and …

Network pharmacology and molecular docking-based identification of drug candidates and key targets of Allium sativum for colorectal cancer treatment

OF Olukunle, V Omoboyede… - Journal of Biomolecular …, 2024 - Taylor & Francis
Colorectal cancer (CRC) is a type of cancer with high morbidity and mortality in several
developing and developed countries of the world. Its mortality and morbidity are predicted to …

[HTML][HTML] The Emerging Role of Blood-Based Biomarkers in Early Detection of Colorectal Cancer: A Systematic Review

F Shweikeh, Y Zeng, AR Jabir, E Whittenberger… - Cancer Treatment and …, 2025 - Elsevier
Background Colorectal cancer (CRC), the third most commonly diagnosed and second most
lethal cancer worldwide, necessitates efficient early detection strategies to improve patient …

eHSP90α in front-line therapy in EGFR exon 19 deletion and 21 Leu858Arg mutations in advanced lung adenocarcinoma

Y Bian, H Liu, J Huang, Z Feng, Y Lin, J Li, L Zhang - BMC cancer, 2024 - Springer
Purpose Extracellular heat shock protein 90 AA1 (eHSP90α) is intricately linked to tumor
progression and prognosis. This study aimed to investigate the difference in the value of …

[PDF][PDF] Extracellular Heat Shock Protein-90 (eHsp90): everything you need to know. Biomolecules. 2022; 12: 911

D Jay, Y Luo, W Li - 2022 - academia.edu
“Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not
formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone …

Exploring the Role of Extracellular Vesicles in Equine Musculoskeletal Pathologies and Associated Regenerative Therapies

EJ Clarke - 2023 - search.proquest.com
Horses are used in a variety of disciplines, including dressage, show jumping, eventing and
racing. Thus, the equine athlete is predisposed to the development of musculoskeletal …