Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to
address the donor shortage as well as immunologic rejection attributed to cells in …

The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Xenotransplantation research has made considerable progress in recent years, largely
through the increasing availability of pigs with multiple genetic modifications. We suggest …

The description of “serum sickness” more than a century ago in humans transfused with
animal sera eventually led to identification of a class of human antibodies directed against …

Abstract Triple-knockout (TKO) pigs (with added protective human transgenes) are likely to
be optimal sources of organs for clinical organ xenotransplantation because many humans …

Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

Background. The aims of this study were to evaluate the efficacy of US Food and Drug
Administration-approved drugs in genetically engineered pig-to-baboon kidney …

Coronary artery bypass grafting (CABG) remains the most common procedure used in
cardiovascular surgery for the treatment of severe coronary atherosclerotic heart disease. In …

Patients with ESKD who would benefit from a kidney transplant face a critical and continuing
shortage of kidneys from deceased human donors. As a result, such patients wait a median …

Background Antibody-mediated rejection is a major cause of graft injury and contributes to
failure of pig xenografts in nonhuman primates (NHPs). Most 'natural'or elicited antibodies …