Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …

Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate
immune-activating stimuli known. Here we review the current understanding of LPS effects …

The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance
between the bacillus and host defense mechanisms. Traditionally, protective immunity to …

The central pathogen-immune interface in tuberculosis is the granuloma, a complex host
immune structure that dictates infection trajectory and physiology. Granuloma macrophages …

In higher organisms a variety of host defense mechanisms control the resident microflora
and, in most cases, effectively prevent invasive microbial disease. However, it appears that …

Mycobacteria are endowed with mechanisms through which they can evade the onslaught
of host defense response. These mechanisms are discussed including diminishing the …

Mycobacterium tuberculosis is one of the most ubiquitous pathogens in the world: estimates
are that roughly one third of the world's population is infected with the bacillus, and it is …

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