Molecularly targeted treatments and immunotherapy are cornerstones in oncology, with
demonstrated efficacy across different tumor types. Nevertheless, the overwhelming majority …

In the field of nanomedicine a multitude of nanovectors have been developed for cancer
application. In this regard, a less exploited target is represented by connective tissue …

Genomic-based precision medicine has not only improved tumour therapy but has also
shown its weaknesses. Genomic profiling and mutation analysis have identified alterations …

Myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS) can be
considered as a spectrum of the same disease entity, representing one of the most common …

Myxofibrosarcoma (MFS) is one of the most common adult soft tissue sarcomas, typically
arising in the extremities. Histologically, MFS is classified into three grades: low …

Mesenchymal tumors of the skin are rare and clinically heterogeneous, and can represent
diagnostic challenge for pathologists. Most of these lesions have overlapping clinical and …

Background Myxofibrosarcoma is a rare malignant soft tissue sarcoma characterised by
multiple local recurrence and can become of higher grade with each recurrence …

Simple Summary Myxofibrosarcomas (MFS) are malignant soft tissue tumors, frequently
located in the extremities. Owing to the infiltrative growth pattern of MFS, neoadjuvant …

Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case
Report and Mechanistic Overview | JCO Precision Oncology Skip to main content ASCO …

Musculoskeletal sarcomas pose major challenges to researchers and clinicians due to their
rarity and heterogeneity. Xenografting human cells or tumor fragments in rodents is a …