The active components from the extracts of Digitalis, cardiotonic steroid glycosides, have
been ingested by humans for more than 200 years as a medicinal therapy for heart failure …

Rigid saturated nitrogen-containing scaffolds such as 3-azabicyclo [3.1. 0] hexanes are very
important and frequently occurring motifs in biologically active compounds. We disclose a …

We herein develop a highly diastereoselective synthesis of cyano-substituted cyclopropanes
via palladium-catalyzed direct cyanoesterification of cyclopropenes, which features mild …

This review is based on the recent synthetic advancements of N‐tosylhydrazone under
metal‐free conditions for the construction of nitrogen‐containing heterocycles. N …

The cyclopropane ring is present in a large number of bioactive molecules as its
incorporation often greatly alters their physiochemical properties. The synthesis of such motif …

Described herein is a palladium-catalyzed borylative cyclization and cyclopropanation of
terminal alkyne-derived enynes, affording borylated bicycles, fused cycles, and bridged …

Conformationally restricted azabicycles are becoming increasingly important in medicinal
research. Asymmetric Heck bicyclization of enynes proceeds to give medicinally useful aza …

A diastereoselective, Pd-catalyzed Suzuki–Miyaura coupling reaction of geminal bis (boryl)
cyclopropanes has been developed. The reaction offers a highly modular approach to the …

Background: A series of spiro-fused heterocyclic compounds containing cyclopropa [a]
pyrrolizidine-2, 3′-oxindole and 3-spiro [3-azabicyclo [3.1. 0]-hexane] oxindole frameworks …

The multi-component 1, 3-dipolar cycloaddition of ninhydrin, α-amino acids (or peptides),
and cyclopropenes for the synthesis of spirocyclic heterocycles containing both 3-azabicyclo …