The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of
triglycerides to high-density lipoprotein cholesterol (TG: HDL-C) is a surrogate marker of IR …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …

Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

Obesity is reaching epidemic proportions with recent worldwide figures estimated at 1.4
billion and rising year‐on‐year. Obesity affects all socioeconomic backgrounds and …

The Metabolic Syndrome in Men (METSIM) study is a population-based study including
10,197 Finnish men examined in 2005–2010. The aim of the study is to investigate …