Oxidative stress is a major driving mechanism in the pathogenesis of COPD. There is
increased oxidative stress in the lungs of COPD patients due to exogenous oxidants in …

Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental
factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide,
however our understanding of cell specific mechanisms underlying COPD pathobiology …

Smoking-induced lung diseases were extremely rare prior to the 20th century. With
commercialization and introduction of machine-made cigarettes, worldwide use skyrocketed …

Rationale: A genetic locus within the FAM13A gene has been consistently associated with
chronic obstructive pulmonary disease (COPD) in genome-wide association studies …

Since COPD is a heterogeneous disease, a specific anti-inflammatory therapy for this
disease has not been established yet. Oxidative stress is recognized as a major …

Reactive oxygen species (ROS) are generally recognized as major products in the cells that
are produced during oxygen utilization, cellular breakdown, and the incomplete degradation …

There is a marked increase in oxidative stress in the lungs of patients with COPD, as
measured by increased exhaled 8-isoprostane, ethane, and hydrogen peroxide in the …

The growing worldwide prevalence of overnutrition and underexertion threatens the gains
that we have made against atherosclerotic cardiovascular disease and other maladies …

Respiratory syncytial viral (RSV) infections are a frequent cause of chronic obstructive
pulmonary disease (COPD) exacerbations, which are a major factor in disease progression …