mRNA capping: biological functions and applications
The 5′ m7G cap is an evolutionarily conserved modification of eukaryotic mRNA. Decades
of research have established that the m7G cap serves as a unique molecular module that …
of research have established that the m7G cap serves as a unique molecular module that …
How cells get the message: dynamic assembly and function of mRNA–protein complexes
M Müller-McNicoll, KM Neugebauer - Nature Reviews Genetics, 2013 - nature.com
Abstract mRNA is packaged into ribonucleoprotein particles called mRNPs. A multitude of
RNA-binding proteins as well as a host of associated proteins participate in the fate of …
RNA-binding proteins as well as a host of associated proteins participate in the fate of …
SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export
M Müller-McNicoll, V Botti… - Genes & …, 2016 - genesdev.cshlp.org
Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by
specific adaptor proteins. How and why cells use numerous different export adaptors is …
specific adaptor proteins. How and why cells use numerous different export adaptors is …
The role of TREX in gene expression and disease
CG Heath, N Viphakone, SA Wilson - Biochemical Journal, 2016 - portlandpress.com
TRanscription and EXport (TREX) is a conserved multisubunit complex essential for
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
embryogenesis, organogenesis and cellular differentiation throughout life. By linking …
Cap-binding complex (CBC)
T Gonatopoulos-Pournatzis, VH Cowling - Biochemical Journal, 2014 - portlandpress.com
The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene
expression. Protein complexes recruited to 7mG mediate key processing events throughout …
expression. Protein complexes recruited to 7mG mediate key processing events throughout …
Transcriptional and post-transcriptional controls for tuning gene expression in plants
Plant biotechnologists seek to modify plants through genetic reprogramming, but our ability
to precisely control gene expression in plants is still limited. Here, we review transcription …
to precisely control gene expression in plants is still limited. Here, we review transcription …
Paraspeckle formation during the biogenesis of long non-coding RNAs
T Naganuma, T Hirose - RNA biology, 2013 - Taylor & Francis
Paraspeckles are unique subnuclear structures that are built around a specific long non-
coding RNA (lncRNA), NEAT1, which is comprised of two isoforms (NEAT1_1 and …
coding RNA (lncRNA), NEAT1, which is comprised of two isoforms (NEAT1_1 and …
The Iws1: Spt6: CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation
SM Yoh, JS Lucas, KA Jones - Genes & development, 2008 - genesdev.cshlp.org
Many steps in gene expression and mRNA biosynthesis are coupled to transcription
elongation and organized through the C-terminal domain (CTD) of the large subunit of RNA …
elongation and organized through the C-terminal domain (CTD) of the large subunit of RNA …
The multi-tasking P-TEFb complex
V Brès, SM Yoh, KA Jones - Current opinion in cell biology, 2008 - Elsevier
P-TEFb (CycT1: Cdk9), the metazoan RNA polymerase II Ser2 C-terminal domain (CTD)
kinase, regulates transcription elongation at many genes and integrates mRNA synthesis …
kinase, regulates transcription elongation at many genes and integrates mRNA synthesis …
hnRNP C tetramer measures RNA length to classify RNA polymerase II transcripts for export
A McCloskey, I Taniguchi, K Shinmyozu, M Ohno - Science, 2012 - science.org
Specific RNA recognition is usually achieved by specific RNA sequences and/or structures.
However, we show here a mechanism by which RNA polymerase II (Pol II) transcripts are …
However, we show here a mechanism by which RNA polymerase II (Pol II) transcripts are …