There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins are well
tolerated, but associated with various statin-associated symptoms (SAS), including statin …

Statins are competitive inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase and
have been used to treat elevated low-density lipoprotein cholesterol (LDL-C) for almost four …

Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …

N-type voltage-gated calcium (Ca V) channels mediate Ca 2+ influx at presynaptic terminals
in response to action potentials and play vital roles in synaptogenesis, release of …

Objectives The myoblast cell line, C2C12, has been utilised extensively in vitro as an
examination model in understanding metabolic disease progression. Although it is …

Cholesterol plays an essential role in determining cell membrane physico-chemical
characteristics and functions. A proper membrane structure is critical in pancreatic β-cells for …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …