ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Background Increasing evidence suggests that microglia experience two distinct
phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a …

Microglia interact with neurons to facilitate synapse plasticity; however, signal (s)
contributing to microglia activation for synapse elimination in pathology are not fully …

Background Peripheral nerve injuries are accompanied by inflammatory reactions, over-
activation of which may hinder recovery. Among pro-inflammatory pathways …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in
complex tissues, however, spatial orientation is lost. Here, we present single-cell …

Adult neurogenesis is an evolutionary conserved process occurring in all vertebrates.
However, striking differences are observed between the taxa, considering the number of …

BACKGROUND: Thromboembolic events, including myocardial infarction (MI) or stroke,
caused by the rupture or erosion of unstable atherosclerotic plaques are the leading cause …