[HTML][HTML] Platelets in sepsis: an update on experimental models and clinical data

A Assinger, WC Schrottmaier, M Salzmann… - Frontiers in …, 2019 - frontiersin.org
Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Role of platelets in detection and regulation of infection

I Portier, RA Campbell - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Platelets are classically known as essential mediators of hemostasis and thrombosis.
However, in recent years, platelets have gained recognition for their inflammatory functions …

[HTML][HTML] Functional significance of the platelet immune receptors GPVI and CLEC-2

J Rayes, SP Watson, B Nieswandt - The Journal of clinical …, 2019 - Am Soc Clin Investig
Although platelets are best known for their role in hemostasis, they are also crucial in
development, host defense, inflammation, and tissue repair. Many of these roles are …

Platelet GPVI (glycoprotein VI) and thrombotic complications in the venous system

G Perrella, M Nagy, SP Watson… - … , and vascular biology, 2021 - Am Heart Assoc
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Start a fire, kill the bug: The role of platelets in inflammation and infection

C Deppermann, P Kubes - Innate immunity, 2018 - journals.sagepub.com
Platelets are the main players in thrombosis and hemostasis; however they also play
important roles during inflammation and infection. Through their surface receptors, platelets …

[HTML][HTML] An insight into recent advances on platelet function in health and disease

PK Chaudhary, S Kim, S Kim - International journal of molecular sciences, 2022 - mdpi.com
Platelets play a variety of roles in vascular biology and are best recognized as primary
hemostasis and thrombosis mediators. Platelets have a large number of receptors and …

[HTML][HTML] Platelet-cancer interplay: molecular mechanisms and new therapeutic avenues

A Braun, HJ Anders, T Gudermann… - Frontiers in …, 2021 - frontiersin.org
Although platelets are critically involved in thrombosis and hemostasis, experimental and
clinical evidence indicate that platelets promote tumor progression and metastasis through a …

[HTML][HTML] Blood platelets in infection: the multiple roles of the platelet signalling machinery

SMG Trivigno, GF Guidetti, SS Barbieri… - International Journal of …, 2023 - mdpi.com
Platelets are classically recognized for their important role in hemostasis and thrombosis but
they are also involved in many other physiological and pathophysiological processes …

Glycoprotein VI-novel target in antiplatelet medication

O Borst, M Gawaz - Pharmacology & therapeutics, 2021 - Elsevier
Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the
main trigger of platelet activation und acute arterial thrombotic occlusion leading to …

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

MH Harbi, CW Smith, PLR Nicolson, SP Watson… - Platelets, 2021 - Taylor & Francis
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve
arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral …