Hippocampal cells segregate positive and negative engrams

M Shpokayte, O McKissick, X Guan, B Yuan… - Communications …, 2022 - nature.com
The hippocampus is involved in processing a variety of mnemonic computations specifically
the spatiotemporal components and emotional dimensions of contextual memory. Recent …

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

DT Pederick, NA Perry-Hauser, H Meng, Z He… - Elife, 2023 - elifesciences.org
The formation of neural circuits requires extensive interactions of cell-surface proteins to
guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G …

Hippocampal cells multiplex positive and negative engrams

M Shpokayte, O McKissick, X Guan, B Yuan… - BioRxiv, 2020 - biorxiv.org
The hippocampus is involved in processing a variety of mnemonic computations including
the spatiotemporal components, as well as the corresponding emotional dimensions, of …

Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

IL Glærum, K Dunville, NP Montaldo, H Kirikae… - bioRxiv, 2022 - biorxiv.org
Cajal-Retzius (CR) cells are a transient type of neuron that populate the postnatal
hippocampus. The role of transient cell types and circuits have been vastly addressed in …

Synaptic cell-adhesion molecule latrophilin-2 is differentially directed to dendritic domains of hippocampal neurons

TR Murphy, RF Amidon, JD Donohue, L Li… - Iscience, 2024 - cell.com
Hippocampal pyramidal cells possess elaborate dendritic arbors with distinct domains that
are targeted with input-specific synaptic sites. This synaptic arrangement is facilitated by …

Autoencoder-based phenotyping of ophthalmic images highlights genetic loci influencing retinal morphology and provides informative biomarkers

PI Sergouniotis, A Diakite, K Gaurav, E Birney… - medRxiv, 2023 - medrxiv.org
Genome-wide association studies (GWAS) have been remarkably successful in identifying
associations between genetic variation and imaging-derived phenotypes. To date, the main …

Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit

IL Glærum, K Dunville, K Moan, M Krause… - …, 2024 - journals.biologists.com
Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal
hippocampus. To understand how the persistence of CR cells influences the maturation of …

The molecular diversity of hippocampal regions and strata at synaptic resolution revealed by integrated transcriptomic and proteomic profiling

E Kaulich, Q Waselenchuk, N Fuerst, K Desch… - bioRxiv, 2024 - biorxiv.org
The molecular diversity of neurons and their synapses underlies the different responses and
plasticity profiles that drive all neural circuits and behavior. While the extent of this diversity …

Entorhinal cortex layer III ADGRL2 expression controls topographical circuit connectivity required for sequence learning

J Donohue, E Liu, L Saab, R Kaur, W Yang… - 2023 - researchsquare.com
The entorhinal cortex and hippocampus are interconnected brain regions required for
episodic learning and memory. For this functional encoding, correct assembly of specific …

[PDF][PDF] DEVELOPMENTAL LATROPHILIN-2 MEDIATED CONTROL OF NEURONAL MORPHOLOGY WITHIN THE ENTORHINAL CORTEX-HIPPOCAMPAL CIRCUIT

E Liu - 2022 - escholarship.org
Neurons are a group of highly diverse cell types that are assignable to various
morphological categories. The most common excitatory neuron type in the brain are known …