Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
Synthesis of some new 1, 3, 4-oxadiazole derivatives and evaluation of their anticancer activity
In this work, some new 2-[(5-((2-acetamidophenoxy) methyl)-1, 3, 4-oxadiazol-2-yl) thio]
acetamide derivatives (4a-4l) were synthesized and studied for their anticancer activity …
acetamide derivatives (4a-4l) were synthesized and studied for their anticancer activity …
Molecular hybrids of substituted phenylcarbamoylpiperidine and 1, 2, 4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and …
Inflammation is a multifaceted phenomenon triggered by potentially active mediators acutely
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …
released arachidonic acid metabolites partially in lipoxygenase (LOX) pathway which are …
Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4, 6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] pyrrolo [3, 4-c] …
A Redzicka, B Wiatrak, I Jęśkowiak-Kossakowska… - Pharmaceuticals, 2023 - mdpi.com
In the present study, we characterize the biological activity of a newly designed and
synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] …
synthesized series of 15 compounds 2-[2-hydroxy-3-(4-substituted-1-piperazinyl) propyl] …
Exploration of 4-tolyl-5-(p-tolyloxymethyl)-4H-1, 2, 4-triazole thioethers as potent 15-LOX inhibitors supported by in vitro, in silico, MD simulation and DNA binding …
Inflammation is an intricate process exacerbated by the sequential release of lipid mediators
during arachidonic acid metabolism through the LOX and COX pathways. The inhibition of …
during arachidonic acid metabolism through the LOX and COX pathways. The inhibition of …
Exploring 2-(benzylthio)-5-(4-nitrophenyl)-1, 3, 4-oxadiazole as antiproliferative agent: Synthesis, single crystal XRD, DFT, Hirshfeld surface analysis, in vitro …
In this investigation, an oxadiazole derivative namely 2-(benzylthio)-5-(4-nitrophenyl)-1, 3, 4-
oxadiazole (2-Btno) was synthesized. The study delves into the exploration of its anticancer …
oxadiazole (2-Btno) was synthesized. The study delves into the exploration of its anticancer …
Synthesis, In Silico Docking Study, and Biological Evaluation of S-Alkylated 1, 3, 4-Oxadiazole Hybrids
Abstract A library of 3-(5-[(substituted benzyl) sulfanyl]-1, 3, 4-oxadiazol-2-yl)-N-substituted
pyridine-2-amines and 2-[(5-{2-[(substituted phenyl) amino] pyridin-3-yl}-2, 3-dihydro-1, 3, 4 …
pyridine-2-amines and 2-[(5-{2-[(substituted phenyl) amino] pyridin-3-yl}-2, 3-dihydro-1, 3, 4 …
Investigations of p-tolyloxy-1,3,4-oxadiazole propionamides as soybean 15-lipoxygenase inhibitors in comforting with in vitro and in silico studies
Inflammatory disorders are the prime contributor to public health issue and the development
of more effective and safer anti-inflammatory drugs in addition to other therapeutic …
of more effective and safer anti-inflammatory drugs in addition to other therapeutic …
Synthesis, in vitro α‐Glucosidase Inhibition, DFT Calculations, and Molecular Docking Studies of Some New Substituted 2,5‐Bis(pyrazolyl)‐1,3,4‐oxadiazoles
F Chaudhry, S Abdullah, M un‐Nisa, A Hayat… - …, 2024 - Wiley Online Library
A pivotal feature of present research study is the synthesis of some new 2, 5‐bis (pyrazolyl)‐
1, 3, 4‐oxadiazoles as promising α‐glucosidase inhibitors. In this regard, a facile reaction …
1, 3, 4‐oxadiazoles as promising α‐glucosidase inhibitors. In this regard, a facile reaction …