Anti-cancer therapy, particularly chemotherapy, damages ovarian follicles and promotes
ovarian failure. The only pharmacological means for protecting the ovaries from …

As the number of young cancer survivors increases, quality of life after cancer treatment is
becoming an ever more important consideration. According to a report from the American …

BACKGROUND Current options for female fertility preservation in the face of cytotoxic
treatments include embryo, oocyte and ovarian tissue cryopreservation. However these …

Increases in delayed childbearing worldwide have elicited the need for a better
understanding of the biological underpinnings and implications of age-related infertility. In …

Aging has been regarded as a treatable condition, and delaying aging could prevent some
diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as …

Premature ovarian failure (POF) is a common cause of infertility in premenopausal women
who are unavoidably exposed to cytotoxic therapy. Radiotherapy is one of the most effective …

Ionizing radiation is a major contributor to male infertility by destroying spermatogenesis.
Therefore, the need for an effective radio-protective agent is evident. The objective of the …

Objective Premature ovarian insufficiency (POI) is a disease with medical, psychological and
reproductive implications, but its common therapies have limited efficacy and a likelihood of …

BACKGROUND New therapeutic approaches in oncology have converted cancer from a
certain death sentence to a chronic disease. However, there are still challenges to be …

Recent studies documented that the selective estrogen receptor modulator tamoxifen
prevents follicle loss and promotes fertility following in vivo exposure of rodents to irradiation …