Bacterial lipoproteins are peripherally anchored membrane proteins that play a variety of
roles in bacterial physiology and virulence in monoderm (single membrane-enveloped, eg …

The spirochetes in the Borrelia burgdorferi sensu lato genospecies group cycle in nature
between tick vectors and vertebrate hosts. The current assemblage of B. burgdorferi sensu …

Lyme disease is on the rise. Caused by a spirochete Borreliella burgdorferi, it affects an
estimated 500,000 people in the United States alone. The antibiotics currently used to treat …

Chlamydia trachomatis is maintained through a complex bi-phasic developmental cycle that
incorporates numerous processes that are poorly understood. This is reflective of the …

The tetracycline repressor (TetR) belongs to the most popular, versatile and efficient
transcriptional regulators used in bacterial genetics. In the tetracycline (Tc) resistance …

The outer membrane (OM) is the front line of leptospiral interactions with their environment
and the mammalian host. Unlike most invasive spirochetes, pathogenic leptospires must be …

Abstract The disciplines of Borrelia (Borreliella) burgdorferi microbiology and Lyme disease
pathogenesis have come to depend on the genetic manipulation of the spirochete …

To accelerate genetic studies on the Lyme disease pathogen Borrelia burgdorferi, we
developed an enhanced CRISPR interference (CRISPRi) approach for isopropyl-β-d …

ABSTRACT The Lyme disease spirochete, Borrelia burgdorferi, persists in nature by
alternatingly cycling between ticks and vertebrates. During each stage of the infectious …

Rickettsia rickettsii is an obligate intracellular, tick-borne bacterium that causes Rocky
Mountain spotted fever. The demanding nature of cultivating these bacteria within host cells …