Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or
mutations in their genes, cause cancer and other diseases. Here, we review the remarkable …

Synthetic photoelectrochemistry (PEC) is receiving increasing attention as a new frontier for
the generation and handling of reactive intermediates. PEC permits selective single …

Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although
originally implicated in the control of cytoskeletal events, it is currently known that these …

Midostaurin was a prototype kinase inhibitor, originally developed as a protein kinase C
inhibitor and subsequently as an angiogenesis inhibitor, based on its inhibition of vascular …

Phosphorylation of myosin II plays an important role in many cell functions, including smooth
muscle contraction. The level of myosin II phosphorylation is determined by activities of …

Pulmonary arterial hypertension (PAH) is a rare disorder characterized by progressive
obliteration of small pulmonary arteries that leads to elevated pulmonary arterial pressure …

Background The blood brain barrier tightly regulates the passage of molecules into the brain
and becomes leaky following obstructive cholestasis. The aim of this study was to determine …

Intracellular signaling pathway mediated by small GTPase Rho and its effector Rho-kinase
plays an important role in regulation of vascular smooth muscle contraction and other …

Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this
cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the …