Biological Activity of Late Transition Metal‐Based Compounds: From Computational and Theoretical Studies to Laboratory Exploration and Beyond
The use of metal compounds such as cisplatin and its derivatives as therapeutic and
diagnostic agents against various diseases is well established. Although metallodrugs have …
diagnostic agents against various diseases is well established. Although metallodrugs have …
Mannose-binding lectins as potent antivirals against SARS-CoV-2
VR Grosche, LPF Souza, GM Ferreira… - Viruses, 2023 - mdpi.com
The SARS-CoV-2 entry into host cells is mainly mediated by the interactions between the
viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated. Therefore …
viral spike protein (S) and the ACE-2 cell receptor, which are highly glycosylated. Therefore …
Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate
MCLC Freire, LGM Basso, LFS Mendes… - Scientific reports, 2022 - nature.com
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile
and arthritogenic illness with no effective treatments available. The development of effective …
and arthritogenic illness with no effective treatments available. The development of effective …
[HTML][HTML] Imidazonaphthyridine effects on Chikungunya virus replication: Antiviral activity by dependent and independent of interferon type 1 pathways
UEA Ruiz, IA Santos, VR Grosche, RS Fernandes… - Virus Research, 2023 - Elsevier
The Chikungunya virus (CHIKV) causes Chikungunya fever, a disease characterized by
symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved …
symptoms such as arthralgia/polyarthralgia. Currently, there are no antivirals approved …
Insights into the role of the cobalt (III)-thiosemicarbazone complex as a potential inhibitor of the Chikungunya virus nsP4
DOS Martins, RAC Souza, MCLC Freire… - JBIC Journal of …, 2023 - Springer
Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disease that can
result in disability. Until now, there is no antiviral treatment against CHIKV, demonstrating …
result in disability. Until now, there is no antiviral treatment against CHIKV, demonstrating …
Triphenylphosphine gold (I) derivatives promote antiviral effects against the Chikungunya virus
Herein a systematic series of four [AuLL'] n+ n= 0,+ 1 complexes, where L= 1, 3-bis (mesityl)
imidazole-2-ylidene (IMes), or triphenylphosphine (PPh3), and L'= chloride, or 4 …
imidazole-2-ylidene (IMes), or triphenylphosphine (PPh3), and L'= chloride, or 4 …
The Dimeric Peptide (KKYRYHLKPF)2K Shows Broad-Spectrum Antiviral Activity by Inhibiting Different Steps of Chikungunya and Zika Virus Infection
GM Ayusso, MLD Lima, PR da Silva Sanches… - Viruses, 2023 - mdpi.com
Chikungunya virus (CHIKV) and Zika virus (ZIKV) are important disease-causing agents
worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these …
worldwide. Currently, there are no antiviral drugs or vaccines approved to treat these …
Exploring the antiviral activities of the FDA-approved drug sulfadoxine and its derivatives against Chikungunya virus
DOS Martins, UEA Ruiz, IA Santos, IS Oliveira… - Pharmacological …, 2024 - Springer
Background Currently, there is no antiviral licensed to treat chikungunya fever, a disease
caused by the infection with Alphavirus chikungunya (CHIKV). Treatment is based on …
caused by the infection with Alphavirus chikungunya (CHIKV). Treatment is based on …
In vitro antiviral activity of piperidine alkaloids from Senna spectabilis flowers on Chikungunya virus infection
Background Chikungunya fever is an endemic disease caused by the Chikungunya virus
(CHIKV). To date there is no antiviral treatment against this infection or licensed vaccine to …
(CHIKV). To date there is no antiviral treatment against this infection or licensed vaccine to …
Antiviral Activity of Pd (II) Complexes with Aminoadamantanes Against Arboviruses
In this paper, we report the synthesis, structural characterization, and antiviral properties of
palladium (II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass …
palladium (II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass …