Among inborn errors of immunity (IEIs), some conditions are characterized by inflammation
and autoimmunity at the front line and are particularly challenging to treat. Monogenic …

Cell‐autonomous sensing of nucleic acids is essential for host defence against invading
pathogens by inducing antiviral and inflammatory cytokines. cGAS has emerged in recent …

One of the oldest mechanisms of immune defense against pathogens is through detection of
foreign DNA. Since human DNA is compartmentalized into the nucleus, its presence in the …

The innate immune systems detect pathogens via pattern-recognition receptors including
nucleic acid sensors and non-nucleic acid sensors. Cyclic guanosine monophosphate …

Over the past two decades, the number of genetically defined autoinflammatory
interferonopathies has steadily increased. Aicardi–Goutières syndrome and proteasome …

Primary immunodeficiency (PID) is no longer defined by infections alone, and autoimmunity
is an accompanying manifestation of PID. Recurrent infections may trigger autoimmunity …

This review comprehensively explores the molecular characterization, genetic insights, and
functional implications of human DNase II, an enzyme crucial for DNA hydrolysis under …

DNase II plays an important role in clearance of nucleic acids by hydrolyzing DNA under 30
acidic conditions. DNAse II deficiency results in inefficient degradation of self DNA, which …

With the advent of widespread next‐generation sequencing, the systemic autoinflammatory
diseases (SAIDs) have emerged as one of the most rapidly expanding groups of monogenic …

Behçet's Disease (BD) is a rare multisystemic variable vessel vasculitis with a chronic and
relapsing disease course. BD is polygenic, and genome wide association studies in cohorts …