Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies
EA Abd El-Meguid, AM Naglah, GO Moustafa… - Bioorganic & Medicinal …, 2022 - Elsevier
A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
Novel benzothiazole hybrids targeting EGFR: Design, synthesis, biological evaluation and molecular docking studies
EA Abd El-Meguid, GO Moustafa, HM Awad… - Journal of Molecular …, 2021 - Elsevier
Novel benzo [d] thiazole-based analogues were synthesized with the aim of screening their
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
in vitro anticancer activity. All the new derivatives 4–21 were evaluated against human …
Advances in 2‐substituted benzothiazole scaffold‐based chemotherapeutic agents
Targeted therapy plays a pivotal role in cancer therapeutics by countering the drawbacks of
conventional treatment like adverse events and drug resistance. Over the last decade …
conventional treatment like adverse events and drug resistance. Over the last decade …
Design, synthesis, and anticancer activity of novel benzothiazole analogues
AY Hassan, MT Sarg… - Journal of Heterocyclic …, 2019 - Wiley Online Library
On the pharmaceutical account of the reported anticancer activity of benzothiazole
derivatives, differently substituted benzothiazole derivatives 2a–c to 34a, b, attached at 2 …
derivatives, differently substituted benzothiazole derivatives 2a–c to 34a, b, attached at 2 …
Synthesis, cytotoxicity of some pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action
EM Husseiny - Bioorganic Chemistry, 2020 - Elsevier
A novel series of pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety
were designed and synthesized. Chemical structures were confirmed by spectral data and …
were designed and synthesized. Chemical structures were confirmed by spectral data and …
Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido [2, 1-b] benzothiazole derivatives
MT Gabr, NS El-Gohary, ER El-Bendary… - European journal of …, 2014 - Elsevier
New series of benzothiazole and pyrimido [2, 1-b] benzothiazole derivatives were
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …
synthesized and characterized by analytical and spectrometrical methods (IR, HRMS, 1 H …
Mechanistic insight and structure activity relationship of isatin-based derivatives in development of anti-breast cancer agents
Breast cancer is most common in women and most difficult to manage that causes highest
mortality and morbidity among all diseases and posing significant threat to mankind as well …
mortality and morbidity among all diseases and posing significant threat to mankind as well …
Green and highly efficient MCR strategy for the synthesis of pyrimidine analogs in water via C–C and C–N bond formation and docking studies
The current study deals with the synthesis of some novel pyrimidine derivatives by the
reaction of aromatic aldehydes, 2-aminobenzothiazole, and dimedone in the presence of …
reaction of aromatic aldehydes, 2-aminobenzothiazole, and dimedone in the presence of …
Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones
S Mor, S Sindhu - Medicinal Chemistry Research, 2020 - Springer
We report a convenient and efficient synthesis of indeno [1, 2-c] pyrazol-4 (1 H)-ones (4a‒o)
by the reaction of a variety of 2-acyl-(1 H)-indene-1, 3 (2 H)-diones (1) and 2 …
by the reaction of a variety of 2-acyl-(1 H)-indene-1, 3 (2 H)-diones (1) and 2 …