Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Risk of disease is multifactorial and can be shaped by socio-economic, demographic,
cultural, environmental and genetic factors. Our understanding of the genetic determinants …

For many complex traits, gene regulation is likely to play a crucial mechanistic role. How the
genetic architectures of complex traits vary between populations and subsequent effects on …

Most existing expression quantitative trait locus (eQTL) mapping studies have been focused
on individuals of European ancestry and are underrepresented in other populations …

Sequencing DNA derived from archaic bones has enabled genetic comparison of
Neanderthals and anatomically modern humans (AMHs), and revealed that they interbred …

Using genetic data to predict gene expression has garnered significant attention in recent
years. PrediXcan has become one of the most widely used gene-based methods for testing …

There has been a rapid increase in human genome sequencing in the past two decades,
resulting in the identification of millions of previously unknown genetic variants. However …

Advances in chromatin state mapping, high-throughput DNA sequencing, and bioinformatics
have revolutionized the study and interpretability of epigenomic variation. The increasing …

It is increasingly recognized that an important step towards improving overall health is to
accurately measure biomarkers of health from the molecular activities prevalent in the oral …

Abstract Background and Objective: Advances in omics open new opportunities for cancer
risk prediction and risk-based screening interventions. However, implementation of risk …