Store-operated calcium channels

M Prakriya, RS Lewis - Physiological reviews, 2015 - journals.physiology.org
Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles

NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Neuronal calcium signaling: function and dysfunction

M Brini, T Calì, D Ottolini, E Carafoli - Cellular and molecular life sciences, 2014 - Springer
Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …

Transient receptor potential channels in the vasculature

S Earley, JE Brayden - Physiological reviews, 2015 - journals.physiology.org
The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

The role of transient receptor potential cation channels in Ca2+ signaling

M Gees, B Colsoul, B Nilius - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
The 28 mammalian members of the super-family of transient receptor potential (TRP)
channels are cation channels, mostly permeable to both monovalent and divalent cations …

Pannexin-1 hemichannel–mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse

T Woehrle, L Yip, A Elkhal, Y Sumi… - Blood, The Journal …, 2010 - ashpublications.org
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR)
stimulation at the immune synapse. We previously reported that TCR stimulation induces the …

Local Ca2+ Entry Via Orai1 Regulates Plasma Membrane Recruitment of TRPC1 and Controls Cytosolic Ca2+ Signals Required for Specific Cell Functions

KT Cheng, X Liu, HL Ong, W Swaim, IS Ambudkar - PLoS biology, 2011 - journals.plos.org
Store-operated Ca2+ entry (SOCE) has been associated with two types of channels: CRAC
channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and …

Intracellular calcium homeostasis and signaling

M Brini, T Calì, D Ottolini, E Carafoli - Metallomics and the Cell, 2013 - Springer
Ca 2+ is a universal carrier of biological information: it controls cell life from its origin at
fertilization to its end in the process of programmed cell death. Ca 2+ is a conventional …

Contribution and regulation of TRPC channels in store-operated Ca2+ entry

KT Cheng, HL Ong, X Liu, IS Ambudkar - Current topics in membranes, 2013 - Elsevier
Store-operated calcium entry (SOCE) is activated in response to depletion of the
endoplasmic reticulum-Ca 2+ stores following stimulation of plasma membrane receptors …

STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

W Zeng, JP Yuan, MS Kim, YJ Choi, GN Huang… - Molecular cell, 2008 - cell.com
The receptor-evoked Ca 2+ signal includes activation of the store-operated channels
(SOCs) TRPCs and the Orais. Although both are gated by STIM1, it is not known how STIM1 …