Recent years have witnessed significant increase in both fundamental and clinical studies
evaluating DDS for osteoarthritis. Steroid encapsulating polymeric microparticles for longer …

Introduction Osteoarthritis is a heterogeneous joint disorder that lacks a clinically meaningful
disease modifying drug. Animal models have been beneficial in understanding basic joint …

Growth plate cartilage has limited self-repair ability, leading to poor bone bridge formation
post-injury and ultimately limb growth defects in children. The current corrective surgeries …

Osteoarthritis (OA) is a joint degenerative disease that has become one of the leading
causes of disability in the world. It is estimated that OA affects 50 million adults in the United …

Rheumatoid arthritis (RA), osteoarthritis (OA), and gout are the most prevalent degenerative
joint diseases (DJDs). The pathogenesis underlying joint disease in DJDs remains unclear …

Extensive preclinical data support the use of intra-articular gene therapy for treating OA.
Translation is beginning to accelerate and six gene therapeutics are in clinical trials …

Background Synovial tissue fibrosis is common in advanced OA with features including the
presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type …

Osteoarthritis is a chronic joint disease characterized by chronic inflammation, progressive
destruction of articular cartilage, and subchondral bone sclerosis. When compared to …

Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options
are so far available. Despite some main pathways contributing to OA are identified its …

Osteoarthritis affects hundreds of millions of people worldwide, and its prevalence is
constantly increasing. While there is currently no treatment that can alter the course of the …