Wiskott‐Aldrich syndrome: a comprehensive review
MJ Massaad, N Ramesh… - Annals of the New York …, 2013 - Wiley Online Library
Wiskott‐Aldrich syndrome (WAS) is a rare X‐linked primary immunodeficiency characterized
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …
by microthrombocytopenia, eczema, recurrent infections, and an increased incidence of …
Autoimmunity in Wiskott–Aldrich syndrome: an unsolved enigma
Wiskott–Aldrich Syndrome (WAS) is a severe X-linked Primary Immunodeficiency that affects
1–10 out of 1 million male individuals. WAS is caused by mutations in the WAS Protein …
1–10 out of 1 million male individuals. WAS is caused by mutations in the WAS Protein …
Actin cytoskeletal defects in immunodeficiency
The importance of the cytoskeleton in mounting a successful immune response is evident
from the wide range of defects that occur in actin‐related primary immunodeficiencies (PID …
from the wide range of defects that occur in actin‐related primary immunodeficiencies (PID …
Wiskott‐Aldrich syndrome protein: emerging mechanisms in immunity
E Rivers, AJ Thrasher - European journal of immunology, 2017 - Wiley Online Library
Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …
Current and emerging treatment options for Wiskott–Aldrich syndrome
AJJ Worth, AJ Thrasher - Expert review of clinical immunology, 2015 - Taylor & Francis
Wiskott–Aldrich syndrome is a life-threatening primary immunodeficiency associated with a
bleeding tendency, eczema and a high incidence of autoimmunity and malignancy. Stem …
bleeding tendency, eczema and a high incidence of autoimmunity and malignancy. Stem …
Outcomes of hematopoietic stem cell gene therapy for Wiskott-Aldrich syndrome
R Labrosse, JI Chu, MA Armant, JK Everett, D Pellin… - Blood, 2023 - ashpublications.org
Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder characterized by combined
immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid …
immunodeficiency, eczema, microthrombocytopenia, autoimmunity, and lymphoid …
Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients
F Pala, H Morbach, MC Castiello… - The Journal of …, 2015 - Am Soc Clin Investig
Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency characterized by
microthrombocytopenia, eczema, and high susceptibility to developing tumors and …
microthrombocytopenia, eczema, and high susceptibility to developing tumors and …
W iskott–A ldrich syndrome protein–dynamic regulation of actin homeostasis: from activation through function and signal termination in T lymphocytes
O Matalon, B Reicher, M Barda‐Saad - Immunological reviews, 2013 - Wiley Online Library
The actin cytoskeleton network forms a key link between T‐cell antigen receptor (TCR)
stimulation and T‐cell effector functions, providing a structural basis for T‐cell morphological …
stimulation and T‐cell effector functions, providing a structural basis for T‐cell morphological …
[HTML][HTML] Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification
M Descatoire, R Fritzen, S Rotman, G Kuntzelman… - Cell Reports, 2022 - cell.com
A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to
autoimmunity. A key contribution of B cells to development of these complications has been …
autoimmunity. A key contribution of B cells to development of these complications has been …
The role of WASp in T cells and B cells
Wiskott-Aldrich syndrome (WAS) is a form of primary immunodeficiency (PIDs) resulting from
mutations of the gene that encodes Wiskott-Aldrich syndrome protein (WASp). WASp is the …
mutations of the gene that encodes Wiskott-Aldrich syndrome protein (WASp). WASp is the …