Background Polygenic scores—which quantify inherited risk by integrating information from
many common sites of DNA variation—may enable a tailored approach to clinical medicine …

Advances in genetics and genomics are transforming medical practice, resulting in a
dramatic growth of genetic testing in the health care system. The rapid development of new …

There is growing interest in communicating clinically relevant DNA sequence findings to
research participants who join projects with a primary research goal other than the clinical …

The first tests of precision medicine ethics in practice will be in clinical oncology, providing a
rare opportunity to shape the agenda and integrate practical ethics considerations. These …

Patients and non-specialist healthcare professionals are increasingly expected to
understand and interpret the results of genetic or genomic testing. These results are …

In laboratory medicine, much effort has been put into analytical quality in the past decades,
making this medical profession one of the most standardized with the lowest rates of error …

Abstract “The objective of this study was to” test the effectiveness of an enhanced genomic
report on patient-centered outcome domains including communication, engagement and …

Precision medicine (PM) has the potential to tailor healthcare to the individual patient by
using their genetic information to guide treatment choices. However, this process is complex …

This study reports on the responses of physicians who reviewed provider and patient
versions of a genomic laboratory report designed to communicate results of whole genome …

A challenge in returning genomic test results to research participants is how best to
communicate complex and clinically nuanced findings to participants in a manner that is …