Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

A dynamic programming algorithm for prediction of RNA secondary structure has been
revised to accommodate folding constraints determined by chemical modification and to …

As key regulators in cellular functions, microRNAs (miRNAs) themselves need to be tightly
controlled. Lin28, a pluripotency factor, was reported to downregulate let-7 miRNA by …

A partition function calculation for RNA secondary structure is presented that uses a current
set of nearest neighbor parameters for conformational free energy at 37° C, including …

The RNA genome of the human immunodeficiency virus type-1 (HIV-1) contains a∼ 120
nucleotide Ψ-packaging signal that is recognized by the nucleocapsid (NC) domain of the …

Viruses play a role in a significant portion of human diseases, as well as those of other
animals, plants, and bacteria. This chapter focuses on the use of theoretical and …

Lin28 is an essential RNA-binding protein that is ubiquitously expressed in embryonic stem
cells. Its physiological function has been linked to the regulation of differentiation …

Viruses with segmented double-stranded (ds) RNA genomes infect a wide range of
organisms including vertebrates, invertebrates, plants, and bacteria and belong to the …

The critical functions of the HIV-1 nucleocapsid protein NCp7 in genomic RNA packaging
and reverse transcription, essentially rely on interactions with nucleic acids. A significant …