Understanding the psychological mechanisms and underlying neurobiology of relapse
behavior is essential for improving the treatment of addiction. Because the neurobiology of …

While rats have been predominantly used to study operant ethanol self-administration
behavior in the context of dependence, several studies have employed operant conditioning …

Alcohol operant self-administration paradigms are critical tools for studying the neural
circuits implicated in both alcohol-seeking and consummatory behaviors and for …

The molecular mechanisms that mediate genetic variability in response to alcohol are
unclear. We found that alcohol had opposite actions (enhancement or suppression) on …

Alcoholism (alcohol dependence and alcohol use disorder, AUD) is quintessentially
behavioral in nature. AUD is behaviorally and genetically complex. This review discusses …

Clinical and epidemiological observations have revealed that alcohol abuse and alcoholism
are associated with widespread disruptions in sleep and other circadian biological rhythms …

Modulation of cholinergic neurotransmission via nicotinic acetylcholine receptors is known
to alter alcohol-drinking behavior. It is not known if muscarinic acetylcholine receptor …

Previous studies in mice and rats have shown that selective breeding for high and low
ethanol preference results in divergence of circadian phenotype in the selected lines. These …

Background In alcohol‐dependent individuals, acute alcohol withdrawal results in severe
physiological disruption, including potentially lethal central nervous system hyperexcitability …

Background While the acute alcohol withdrawal syndrome has been well characterized both
in human clinical studies and in experimental animals, much less is known regarding long …