Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …

Immunotherapies such as checkpoint-blocking antibodies and adoptive cell transfer are
emerging as treatments for a growing number of cancers. Despite clinical activity of …

Gliomas are brain tumors characterized by an immunosuppressive microenvironment.
Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Simple Summary In breast cancer, there is a high degree of variability in tumors and the
surrounding tissue called the tumor microenvironment (TME). To better understand tumor …

Background The degree of immune infiltration in tumors, especially CD8+ T cells, greatly
impacts patient disease course and response to interventional immunotherapy …

The complex tumor microenvironment (TME) plays a vital role in cancer development and
dramatically determines the efficacy of immunotherapy. Tertiary lymphoid structures (TLSs) …

Great progress has been made in the field of tumor immunotherapy in the past decade.
However, the therapeutic effects of immune checkpoint blockade (ICB) against ovarian …

Purpose: Combination strategies leveraging chemotherapeutic agents and immunotherapy
have held the promise as a method to improve benefit for patients with cancer. However …

Immune checkpoint inhibitor therapy has changed clinical practice for patients with different
cancers, since these agents have demonstrated a significant improvement of overall survival …