Abstract Sirtuin-3 (SIRT3) is a NAD+-dependent protein deacetylase that is located in
mitochondria, regulating mitochondrial proteins and maintaining cellular antioxidant status …

Sirtuins belong to an evolutionarily conserved family of NAD+-dependent deacetylases that
share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy …

Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including
heart disease, cancer, neurodegenerative diseases, and the general aging process …

Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative
decarboxylation of isocitrate to α-ketoglutarate (αKG), NAD (P) H, and CO2. IDHs …

The relative contributions of different mitochondrial and cytosolic sources of superoxide and
hydrogen peroxide in cells are not well established because of a lack of suitable quantitative …

Cryodamage affects the normal physiological functions and survivability of boar sperm
during cryopreservation. Lysine acetylation is thought to be an important regulatory …

Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of
isocitrate to α-ketoglutarate (α-KG). Mutations in IDH lead to loss of normal enzymatic activity …

Glioma is one of the most common types of brain tumors, and its high recurrence and
mortality rates threaten human health. In 2008, the frequent isocitrate dehydrogenase 1 …

Background Although isocitrate dehydrogenase 2 (IDH2) mutations have been the hotspots
in recent anticancer studies, the impact of wild-type IDH2 on cancer cell growth and …

Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial
discovery that SIRTs could promote longevity in nematodes and flies, the identification of …