Interleukin-2 (IL-2), the first cytokine that was molecularly cloned, was shown to be a T cell
growth factor essential for the proliferation of T cells and the generation of effector and …

Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters human host cells
via angiotensin-converting enzyme 2 (ACE2) and causes coronavirus disease 2019 (COVID …

To identify genetic variation underlying atrial fibrillation, the most common cardiac
arrhythmia, we performed a genome-wide association study of> 1,000,000 people, including …

Human T cells are central effectors of immunity and cancer immunotherapy. CRISPR-based
functional studies in T cells could prioritize novel targets for drug development and improve …

Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many
scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent …

Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2
cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL) …

The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …

The atopic march recognizes the increased occurrence of asthma, allergic rhinitis, or both
after atopic dermatitis (AD) onset. Mechanisms for developing atopic comorbidities after AD …

Visceral adipose tissue (VAT)—fat stored around the internal organs—has been suggested
as an independent risk factor for cardiovascular and metabolic disease–, as well as all …