Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

Microbial infections are recognized by the innate immune system both to elicit immediate
defense and to generate long-lasting adaptive immunity. To detect and respond to vastly …

The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

The body is host to a wide variety of microbial communities from which the immune system
protects us and that are important for the normal development of the immune system and for …

Kupffer cells, the liver tissue resident macrophages, are critical in the detection and
clearance of cancer cells. However, the molecular mechanisms underlying their detection …

It is known that interactions between nociceptors and dendritic cells (DCs) can modulate
immune responses in barrier tissues. However, our understanding of the underlying …

Candida albicans is a common fungal pathogen of humans that colonizes the skin and
mucosal surfaces of most healthy individuals. Until recently, little was known about the …

Twenty years after the proposal that pattern recognition receptors detect invasion by
microbial pathogens, the field of immunology has witnessed several discoveries that have …

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor
signalling. However, recent reports indicate that SYK also mediates other, unexpectedly …