Microalgae exhibit great potential for recombinant therapeutic protein production, due to
lower production costs, immunity to human pathogens, and advanced genetic toolkits …

Mammalian expression platforms are primary production systems for therapeutic proteins
that require complex post-translational modifications. Current processes used for developing …

Engineering mammalian cell lines that stably express many transgenes requires the precise
insertion of large amounts of heterologous DNA into well-characterized genomic loci, but …

Diatoms are photosynthetic microeukaryotes that dominate phytoplankton populations and
have increasing applicability in biotechnology. Uncovering their complex biology and …

Chinese hamster ovary (CHO) cells are the most widely used mammalian hosts for
recombinant protein production. However, by conventional random integration strategy …

Many branches of biology depend on stable and predictable recombinant gene expression,
which has been achieved in recent years through targeted integration of the recombinant …

Generation of recombinant Chinese hamster ovary (rCHO) cell lines is critical for the
production of therapeutic proteins. However, the high degree of phenotypic heterogeneity …

Chinese hamster ovary (CHO) cells are utilized as primary mammalian expression host cells
for the production of biopharmaceuticals. Recombinant CHO cell line development (CLD) …

The use of targeted integration for industrial CHO cell line development currently requires
significant upfront effort to identify genomic loci capable of supporting multigram per liter …

Initiating and regulating humoral immunity, Fc gamma receptors (FcγRs) have been
identified both as therapeutics and as drug targets, and thus production of biologically active …