Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Recent advances in systems and synthetic biology approaches for developing novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris

P Cai, X Wu, J Deng, L Gao, Y Shen… - Proceedings of the …, 2022 - National Acad Sciences
Methanol-based biorefinery is a promising strategy to achieve carbon neutrality goals by
linking CO2 capture and solar energy storage. As a typical methylotroph, Pichia pastoris …

The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2

T Gassler, M Sauer, B Gasser, M Egermeier… - Nature …, 2020 - nature.com
The methylotrophic yeast Pichia pastoris is widely used in the manufacture of industrial
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …

Engineering of Saccharomyces cerevisiae as a consolidated bioprocessing host to produce cellulosic ethanol: Recent advancements and current challenges

J Sharma, V Kumar, R Prasad, NA Gaur - Biotechnology advances, 2022 - Elsevier
Lignocellulosic biomass, a rich and inexpensive source of fermentable and renewable
carbon, is the most abundant material on earth. Microbial bioprocessing of lignocellulosic …

[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control

G Chen, JL Harwood, MJ Lemieux, SJ Stone… - Progress in Lipid …, 2022 - Elsevier
Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

The potential of CO2-based production cycles in biotechnology to fight the climate crisis

S Bachleitner, Ö Ata, D Mattanovich - Nature Communications, 2023 - nature.com
Rising CO2 emissions have pushed scientists to develop new technologies for a more
sustainable bio-based economy. Microbial conversion of CO2 and CO2-derived carbon …

Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin

Y Jing, Y Wang, D Zhou, J Wang, J Li, J Sun… - Biotechnology …, 2022 - Elsevier
Carotenoids are natural pigments that widely exist in nature. Due to their excellent
antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in …

The oxygen-tolerant reductive glycine pathway assimilates methanol, formate and CO2 in the yeast Komagataella phaffii

BM Mitic, C Troyer, L Lutz, M Baumschabl… - Nature …, 2023 - nature.com
The current climatic change is predominantly driven by excessive anthropogenic CO2
emissions. As industrial bioprocesses primarily depend on food-competing organic …

[HTML][HTML] Development of synthetic biology tools to engineer Pichia pastoris as a chassis for the production of natural products

J Gao, L Jiang, J Lian - Synthetic and systems biotechnology, 2021 - Elsevier
The methylotrophic yeast Pichia pastoris (aka Komagataella phaffii) is one of the most
commonly used hosts for industrial production of recombinant proteins. As a non …