Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

The innate immune system plays a pivotal role in the first line of host defense against
infections and is equipped with patterns recognition receptors (PRRs) that recognize …

Toll‐like receptors (TLRs) are the most studied receptors among the pattern recognition
receptors (PRRs). They act as microbial sensors, playing major roles in the regulation of the …

Receptor for advanced glycation end products (RAGE) is a 45 kDa transmembrane receptor
of immunoglobulin family that can bind to various endogenous and exogenous ligands and …

Simple Summary Due to the broad functions of Toll-like receptor 2 (TLR2) in innate
immunity, the drive for the development of TLR2-targeted therapeutic treatments has …

Dysregulation of the innate immune system and inflammatory-related pathways has been
implicated in hematopoietic defects in the bone marrow microenvironment and associated …

Brucellosis is considered one of the most hazardous zoonotic diseases all over the world. It
causes formidable economic losses in developed and developing countries. Despite the …

While a certain level of inflammation is critical for humans to survive infection and injury, a
prolonged inflammatory response can have fatal consequences. Pattern recognition Toll-like …

Pyroptosis, characterized as an inflammasome-mediated cell death pathway, may be
participated in tumorigenesis and progression. However, the underlying molecular function …

The role of TIRAP (toll/interleukin-1 receptor (TIR) domain-containing adapter protein) in
macrophage inflammatory signalling has been significantly evolved since its discovery in …